Week Three on First Down Friday Night featured some intense matchups in region play across the Tennessee Valley.
- Sparkman vs Grissom
- Florence vs Bob Jones
- Austin vs Gadsden City
- James Clemens vs Huntsville
- Guntersville vs Scottsboro
- Woodville vs Gaylesville
- Brewer vs Madison Academy
- Randolph vs Priceville
- Muscle Shoals vs Hartselle
- Athens vs Decatur
- Cullman vs Columbia
- Mae Jemison vs Fort Payne
- Albertville vs Buckhorn